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July 30.2025
2 Minutes Read

Valacyclovir Fails to Slow Alzheimer's: A Closer Look at the Trial's Results

Illustration of neurons and amyloid plaques related to Alzheimer's.

Valacyclovir and Alzheimer's: What We Learned

Recent research has raised questions about the relationship between Alzheimer’s disease and a common herpes drug, valacyclovir. In a trial called VALAD, involving older adults with early Alzheimer’s, it was discovered that valacyclovir did not provide any benefit. The trial explored whether this antiviral drug, used mainly to treat herpes simplex virus infections, could help improve cognitive abilities in individuals with Alzheimer’s.

According to Dr. Davangere P. Devanand from Columbia University, the results of the trial showed that those taking valacyclovir actually experienced greater cognitive decline compared to those taking a placebo. On the Alzheimer's Disease Assessment Scale-Cognitive subscale, participants taking valacyclovir scored worse, indicating a concerning outcome (ave. difference of 3.91 points). While valacyclovir is generally considered safe, this trial did not support its use for treating Alzheimer’s.

Understanding the Connection: Herpes and Alzheimer's

The research behind using valacyclovir for Alzheimer's comes from intriguing theories suggesting a link between herpes viruses and neurodegenerative diseases. Specifically, some studies have indicated that herpes simplex virus type 1 (HSV-1), which often causes cold sores, might play a role in Alzheimer's development when combined with the genetic risk factor APOE4. However, the VALAD trial didn't find any strong evidence to back this idea, highlighting the complexity of such relationships in medical science.

Key Findings: The VALAD Trial

VALAD was a phase II proof-of-concept trial that tested whether repurposing the herpes medication could possibly help alleviate cognitive symptoms in Alzheimer’s patients. The study was limited to 120 participants, mainly older adults with mild Alzheimer's symptoms and known herpes infections. Despite the drug's well-known safety profile, the trial revealed that valacyclovir did not stop cognitive decline or improve daily functioning.

Mixed Evidence on Herpes and Alzheimer's

The link between Alzheimer's and herpes viruses remains a debated topic among scientists. While the VALAD trial did not find a beneficial effect of valacyclovir, some research suggests that HSV-1 could lead to brain changes that might be related to Alzheimer’s symptoms. Understanding this connection better could help guide future treatment approaches or preventive strategies.

What Comes Next?

As researchers continue to explore Alzheimer’s disease, the recent trial adds to our understanding of potential treatments. The search for effective therapies remains critical, especially as Alzheimer’s diagnoses increase with an aging population. The disappointment in valacyclovir’s efficacy illustrates the challenges scientists face in finding successful Alzheimer’s interventions.

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12.29.2025

Analyzing Donald Trump's Health: What His Condition Means for the Future

Update Understanding Trump's Health: A Generational Look This year, questions surrounding President Donald Trump's health have been prominent as he approaches his 80th birthday. Mysterious bruising on his hands, severe swelling in his ankles, and instances of dozing off have drawn the attention of the public and health experts alike. While Trump insists he enjoys excellent health, geriatricians provide context about the typical aging process and how it impacts health at his age. What is Chronic Venous Insufficiency? Among the most significant health developments has been Trump's diagnosis of chronic venous insufficiency (CVI). This common condition occurs when the veins in the legs cannot pump blood back toward the heart effectively, leading to pooling blood, swollen limbs, and potential complications if untreated. With CVI affecting an estimated one in three adults in the U.S., Trump's diagnosis serves as a reminder of this widespread issue. Keeping Health in Perspective as We Age As time goes on, older adults like Trump may experience symptoms that seem alarming but are often considered normal aspects of aging. Feeling fatigued or dozing off during mid-day meetings could be typical for nearly-octogenarians, even those in high-pressure roles like the presidency. According to geriatrician Eric Widera, Trump’s active schedule indicates that while he shows signs of aging, he does not exhibit cognitive impairment. Public Perception vs. Medical Reality Media coverage surrounding Trump's health has included sensational rumors, particularly during times he has appeared public less frequently. In response to these uncertainties, it's essential for President Trump and the public to understand the implications of health diagnoses, especially as they pertain to leadership roles. Trump's health assessments, including cognitive evaluations that he scored perfectly on, suggest he maintains a level of functionality expected of someone in his position. Implications of Trump’s Health for the Future The ongoing scrutiny surrounding Trump’s health reinforces the conversation about older politicians and leaders in our society. As technology and medicine continue to advance, it’s vital for citizens to engage with and understand these changes, particularly regarding how they affect our older citizens—like our leaders. This awareness can foster discussions not only about our leaders but also about the healthcare policies they advocate for. Recognizing Symptoms Early Trump’s experiences also open the door to discuss common health issues among older adults. Symptoms like swelling, fatigue, and changes in skin texture should encourage timely medical evaluations. Addressing these signs early can reduce the risk of serious complications down the line, exemplifying the importance of proactive health management. For those concerned about CVI or similar conditions, seeking medical advice is vital. Regular movement, wearing compression stockings, and staying hydrated can significantly improve vascular health and overall well-being. Knowledge of these strategies is crucial, especially for older individuals. Conclusion President Trump's year in health showcases the mixed reality many face as they age. Not only does it reflect personal health challenges, but it also serves as a pivotal point for public discourse around the health of older leaders. As the case of Trump's health unfolds, it encourages us to be vigilant regarding health symptoms and to seek medical advice when necessary.

12.27.2025

Explore the Surprising Health Benefits of Belly Laughs for Everyone

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12.23.2025

Exploring the Connection Between Air Pollution and Depression: What It Means for Seniors

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